Nucleic Acid Delivery

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Nucleic acids, such as mRNA, can be used to induce cells to express proteins, including proteins that are capable of re-writing genetic and epigenetic cellular programs. However, nucleic acids are susceptible to degradation by intracellular and extracellular nucleases and can trigger immune responses that can block protein translation and cause cell death. The plasma membrane also protects cells from exogenous nucleic acids, preventing efficient uptake and protein translation.

We develop technologies for delivering nucleic acids to cells ex vivo and in vivo.

Our nucleic acid delivery technologies enable efficient ex vivo delivery of mRNA encoding gene-editing proteins and reprogramming factors, including to primary cells, insertion of exogenous DNA sequences into defined genomic loci, and efficient in vivo delivery of mRNA to the brain, eye, skin, and lung.