Cell Reprogramming & Gene Editing

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Cells contain two programs that work together to determine their behavior. A genetic program, written in the sequence of a cell’s DNA, encodes information about each protein that the cell produces, while an epigenetic program not encoded in the sequence of a cell’s DNA determines other heritable characteristics, including the amount of each protein produced. These two programs ensure that the trillions of cells that make up a complex multicellular organism act in concert to perform the many specialized functions needed for the organism to survive and grow.

We develop technologies to re-write these two cellular programs to treat disease and improve the way cells function.

Our gene-editing technologies enable the precise deletion, insertion, and repair of DNA sequences in living cells to correct disease-causing mutations, make cells resistant to infection and degenerative disease, modulate the expression of immunoregulatory proteins to enable the generation of durable allogeneic cell therapies, and engineer immune cells to more effectively fight cancer.

Our cell-reprogramming technologies enable the generation of clonal lines of pluripotent stem cells that can be expanded and differentiated into any desired cell type for the development of regenerative cell therapies.